Open Access Books
ECO-COMPASS: Ecological and Multifunctional Composites for Application in Aircraft Interior and Secondary Structures
Today, mainly man-made materials, such as carbon and glass fibers, are used to produce composite parts in aviation. Renewable materials, such as natural fibers or bio-sourced resin systems, have not yet found their way into aviation. The project ECO-COMPASS aims to evaluate the potential applications of ecologically improved composite materials in the aviation sector in an international collaboration of Chinese and European partners. Natural fibers such as flax and ramie will be used for different types of reinforcements and sandwich cores. Furthermore, bio-based epoxy resins to substitute bisphenol-A based epoxy resins in secondary structures are under investigation. Adapted material protection technologies to reduce environmental influence and to improve fire resistance are needed to fulfil the demanding safety requirements in aviation. Modelling and simulation of chosen eco-composites aims for an optimized use of materials while a Life Cycle Assessment aims to prove the ecological advantages compared to synthetic state-of-the-art materials. This Special Issue provides selected papers from the project consortium partners.
Eating Disorders and Obesity: The Challenge for Our Times
Eating Disorders have traditionally been considered apart from public health concerns about increasing obesity. It is evident that these problems are, however, related in important ways. Comorbid obesity and eating disorder is increasing at a faster rate than either obesity or eating disorders alone and one in five people with obesity also presents with an Eating Disorder, commonly but not limited to Binge Eating Disorder. New disorders have emerged such as normal weight or Atypical Anorexia Nervosa. However research and practice too often occurs in parallel with a failure to understand the weight disorder spectrum and consequences of co-morbidity that then contributes to poorer outcomes for people living with a larger size and an Eating Disorder. Urgently needed are trials that will inform more effective assessment, treatment and care where body size and eating disorder symptoms are both key to the research question.
Religion and Cult in the Dodecanese during the First Millennium BC: Proceedings of the International Archaeological Conference
Religion and Cult in the Dodecanese during the First Millennium BC publishes the proceedings of the conference of the same name, held in Rhodes in October 2018. Religion has always been one of the major components of peoples’ lives, an integral part of social, economic and political contexts, contributing to the formation of culture and history. In order to study and understand the religious and cult practices of a particular region, it is necessary to explore their various expressions through material culture and written sources. The oldest known cult remains in the Dodecanese can be dated to the end of the 10th and early 9th centuries BC and throughout the 1st millennium BC. They demonstrate the existence of a vibrant island society with various evolving cult practices. As a major stopover on maritime trade routes, the southeastern Aegean was influenced by contacts from throughout the Greek world and beyond. The contributions to this volume draw on archaeological and literary sources to explore both the development and continuity of cults in the Dodecanese, from the Early Iron Age through to the 1st century BC.
Earth Observation for Water Resource Management in Africa
Earth Observation for Water Resource Management in Africa
Dynamics Days Latin America and the Caribbean 2018
This book contains various works presented at the Dynamics Days Latin America and the Caribbean (DDays LAC) 2018. Since its beginnings, a key goal of the DDays LAC has been to promote cross-fertilization of ideas from different areas within nonlinear dynamics. On this occasion, the contributions range from experimental to theoretical research, including (but not limited to) chaos, control theory, synchronization, statistical physics, stochastic processes, complex systems and networks, nonlinear time-series analysis, computational methods, fluid dynamics, nonlinear waves, pattern formation, population dynamics, ecological modeling, neural dynamics, and systems biology.
The interested reader will find this book to be a useful reference in identifying ground-breaking problems in Physics, Mathematics, Engineering, and Interdisciplinary Sciences, with innovative models and methods that provide insightful solutions.
This book is a must-read for anyone looking for new developments of Applied Mathematics and Physics in connection with complex systems, synchronization, neural dynamics, fluid dynamics, ecological networks, and epidemics.
Dynamical Models of Biology and Medicine
Mathematical and computational modeling approaches in biological and medical research are experiencing rapid growth globally. This Special Issue Book intends to scratch the surface of this exciting phenomenon. The subject areas covered involve general mathematical methods and their applications in biology and medicine, with an emphasis on work related to mathematical and computational modeling of the complex dynamics observed in biological and medical research. Fourteen rigorously reviewed papers were included in this Special Issue. These papers cover several timely topics relating to classical population biology, fundamental biology, and modern medicine. While the authors of these papers dealt with very different modeling questions, they were all motivated by specific applications in biology and medicine and employed innovative mathematical and computational methods to study the complex dynamics of their models. We hope that these papers detail case studies that will inspire many additional mathematical modeling efforts in biology and medicine
Drug Metabolism, Pharmacokinetics and Bioanalysis
Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
Drinking Water Quality and Human Health
The quality of drinking water is paramount for public health. Despite important improvements in the last decades, access to safe drinking water is not universal. The World Health Organization estimates that almost 10% of the population in the world do not have access to improved drinking water sources. Among other diseases, waterborne infections cause diarrhea, which kills nearly one million people every year, mostly children under 5 years of age. On the other hand, chemical pollution is a concern in high-income countries and an increasing problem in low- and middle-income countries. Exposure to chemicals in drinking water may lead to a range of chronic non-communicable diseases (e.g., cancer, cardiovascular disease), adverse reproductive outcomes, and effects on children’s health (e.g., neurodevelopment), among other health effects. Although drinking water quality is regulated and monitored in many countries, increasing knowledge leads to the need for reviewing standards and guidelines on a nearly permanent basis, both for regulated and newly identified contaminants. Drinking water standards are mostly based on animal toxicity data, and more robust epidemiologic studies with accurate exposure assessment are needed. The current risk assessment paradigm dealing mostly with one-by-one chemicals dismisses the potential synergisms or interactions from exposures to mixtures of contaminants, particularly at the low-exposure range. Thus, evidence is needed on exposure and health effects of mixtures of contaminants in drinking water. Finally, water stress and water quality problems are expected to increase in the coming years due to climate change and increasing water demand by population growth, and new evidence is needed to design appropriate adaptation policies.
This Special Issue of International Journal of Environmental Research and Public Health (IJERPH) focuses on the current state of knowledge on the links between drinking water quality and human health.
DNA Replication Stress
This Special Issue of International Journal of Molecular Sciences (IJMS) is dedicated to the mechanisms mediated at the molecular and cellular levels in response to adverse genomic perturbations and DNA replication stress. The relevant proteins and processes play paramount roles in nucleic acid transactions to maintain genomic stability and cellular homeostasis. A total of 18 articles are presented which encompass a broad range of highly relevant topics in genome biology. These include replication fork dynamics, DNA repair processes, DNA damage signaling and cell cycle control, cancer biology, epigenetics, cellular senescence, neurodegeneration, and aging.
As Guest Editor for this IJMS Special Issue, I am very pleased to offer this collection of riveting articles centered on the theme of DNA replication stress. The blend of articles builds upon a theme that DNA damage has profound consequences for genomic stability and cellular homeostasis that affect tissue function, disease, cancer, and aging at multiple levels and through unique mechanisms. I thank the authors for their excellent contributions, which provide new insight into this fascinating and highly relevant area of genome biology.
Distributed Energy Resources Management
At present, the impact of distributed energy resources in the operation of power and energy systems is unquestionable at the distribution level, but also at the whole power system management level. Increased flexibility is required to accommodate intermittent distributed generation and electric vehicle charging. Demand response has already been proven to have a great potential to contribute to an increased system efficiency while bringing additional benefits, especially to the consumers. Distributed storage is also promising, e.g., when jointly used with the currently increasing use of photovoltaic panels.
This book addresses the management of distributed energy resources. The focus includes methods and techniques to achieve an optimized operation, to aggregate the resources, namely, by virtual power players, and to remunerate them. The integration of distributed resources in electricity markets is also addressed as a main drive for their efficient use.
Discontinuous Fiber Composites
Discontinuous fiber-reinforced polymers have gained importance in the transportation industries due to their outstanding material properties, lower manufacturing costs and superior lightweight characteristics. One of the most attractive attributes of discontinuous fiber reinforced composites is the ease with which they can be manufactured in large numbers, using injection and compression molding processes.
Typical processes involving discontinuous fiber reinforced thermoplastic composite materials include injection and compression molding processes as well as extrusion. Furthermore, the automotive and appliance industries also use thermosets reinforced with chopped fibers in the form of sheet molding compound and bulk molding compound, for compression and injection-compression molding processes, respectively.
A big disadvantage of discontinuous fiber composites is that the configuration of the reinforcing fibers is significantly changed throughout production process, reflected in the form of fiber attrition, excessive fiber orientation, fiber jamming and fiber matrix separation. This process-induced variation of the microstructural fiber properties within the molded part introduces heterogeneity and anisotropies to the mechanical properties, which can limit the potential of discontinuous fiber reinforced composites for lightweight applications.
The main aim of this Special Issue is to collect various investigations focused on the processing of discontinuous fiber reinforced composites and the effect processing has on fiber orientation, fiber length and fiber density distributions throughout the final part. Papers presenting investigations on the effect fiber configurations have on the mechanical properties of the final composite products and materials are welcome in the Special Issue. Researchers who are modeling and simulating processes involving discontinuous fiber composites as well as those performing experimental studies involving these composites are welcomed to submit papers. Authors are encouraged to present new models, constitutive laws and measuring and monitoring techniques to provide a complete framework on these groundbreaking materials and facilitate their use in different engineering applications.
Disability Human Rights Law 2018
Disability human rights law is a rapidly growing field. It merges critical disability studies, disability rights, and human rights to inform, identify, analyse, and create solutions to help protect the human rights of people with disabilities. This is the second volume of the Disability Human Rights Law edited collection. This volume delves deeper into this emerging field and begins to explore what human rights law means for people with disabilities, as well as what innovations people with disabilities are bringing to the field of human rights law.
Practice and Prestige: An Exploration of Neolithic Warfare, Bell Beaker Archery, and Social Stratification from an Anthropological Perspective
Practice and Prestige: An Exploration of Neolithic Warfare, Bell Beaker Archery, and Social Stratification from an Anthropological Perspective investigates the appearance of the ‘archer’s package’ in select Bell Beaker burials raising questions of daily life, warfare, and social stratification during the Neolithic period. It draws on a recent study by the author that applied an anthropological methodology to assess the bone morphology of these skeletons for signs of specialised archery activity. These analyses revealed results at both a population as well as an individual level. In order to contextualise these osteological findings, the book explores the evidence for warfare and archery throughout the Neolithic period in general and the Bell Beaker period in particular. This perspective considers warfare to be a primary function of archery, thereby associating ‘archer’ burials with concepts of warfare and the warrior. A second perspective delves into prehistoric concepts of specialisation and social hierarchy in order to situate archers, archery, and warfare within potentially stratified populations. These two perspectives allow for the contextualisation of the anthropological results within a broad archaeological framework in which archers and archery were prominent parts of a complex Bell Beaker society.
Dinophysis Toxins: Distribution, Fate in Shellfish and Impacts
Several species of Dinophysis produce one or two groups of lipophilic toxins: okadaic acid (OA) and its derivatives; or the dinophysistoxins (DTXs) (also known as diarrhetic shellfish poisons or DSP toxins) and pectenotoxins (PTXs). DSP toxins are potent inhibitors of protein phosphatases, causing gastrointestinal intoxication in consumers of contaminated seafood. Forty years after the identification of Dinophysis as the causative agent of DSP in Japan, contamination of filter feeding shellfish exposed to Dinophysis blooms is recognized as a problem worldwide. DSP events affect public health and cause considerable losses to the shellfish industry. Costly monitoring programs are implemented in regions with relevant shellfish production to prevent these socioeconomic impacts. Harvest closures are enforced whenever toxin levels exceed regulatory limits (RLs). Dinophysis species are kleptoplastidic dinoflagellates; they feed on ciliates (Mesodinium genus) that have previously acquired plastids from cryptophycean (genera Teleaulax, Plagioselmis, and Geminigera) nanoflagellates. The interactions of Dinophysis with different prey regulate their growth and toxin production. When Dinophysis cells are ingested by shellfish, their toxins are partially biotransformed and bioaccumulated, rendering the shellfish unsuitable for human consumption. DSP toxins may also affect shellfish metabolism. This book covers diverse aspects of the abovementioned topics—from the laboratory culture of Dinophysis and the kinetics of uptake, transformation, and depuration of DSP toxins in shellfish to Dinophysis population dynamics, the monitoring and regulation of DSP toxins, and their impact on the shellfish industry in some of the aquaculture regions that are traditionally most affected, namely, northeastern Japan, western Europe, southern Chile, and New Zealand.
Dietary Protein and Muscle in Aging People
This Special Issue of Nutrients, entitled “Dietary Proteins and Muscle in Aging People”, welcomes the submission of manuscripts either reporting original research or reviewing the scientific literature. Manuscripts should focus on the mechanisms linking dietary protein with muscle quality and quantity. Articles presenting results from clinical trials testing protein interventions on muscle mass and function are welcome. The Special Issue aims at including articles spanning different disciplines to explore the topic of interest. Reports from basic to clinical and population research are suitable. Articles adopting a longitudinal approach or reporting data from life-long interventions/observations in the exploration of the theme will be given special consideration.
Potential topics include, but are not limited to:
Description of patterns of dietary protein consumption across life
Influence of dietary protein intake on the functional status of older people
Preclinical and clinical studies describing the mechanisms through which protein intake modifies muscle mass and function
Protein/amino acid supplementation interventions against sarcopenia, cachexia, or disease conditions associated with muscle wasting in old age
Disease-specific alterations modifying the effects of dietary protein intake on skeletal muscles
Effects of the interactions of dietary protein intake and gut microbiota on skeletal muscles
Dietary Fructose and Glucose: The Multifacetted Aspects of Their Metabolism and Implication For Human Health
Dietary Fructose and Glucose: The Multifacetted Aspects of Their Metabolism and Implication for Human Health
Dietary Antioxidants and Prevention of Non-Communicable Diseases
Numerous epidemiological studies have demonstrated the association between oxidative stress and non-communicable disease, including cardiovascular disorders, mental disease, and several types of cancer. Oxidative stress is commonly known as an imbalance in the production of reactive oxygen species (ROS) and the biological antioxidant defense system. Exogenous antioxidants have gained great attention because of their beneficial role in preventing chronic disease. A balanced diet contains hundreds of naturally occurring antioxidant compounds, including polyphenols and vitamins. Antioxidants are commonly found in vegetables, fruits, cocoa, grain cereals, olive oil, nuts and beverages, such as coffee and tea.This book presents original research and reviews of literature concerning dietary antioxidants and human health.
Diet in Brain Health and Neurological Disorders: Risk Factors and Treatments
The role of nutrition in health and disease has been appreciated from time immemorial. Around 400 B.C., Hippocrates wrote “Let food by thy medicine and medicine be thy food.” In the 12th century, the great philosopher and physician Moses Maimonides wrote “any disease that can be treated by diet should be treated by no other means.” Now, in the 21st century, we are bombarded by claims in the media of “superfoods,” wondrous nutritional supplements, and special diets that promise to cure or prevent disease, improve health and restore functioning. Much of the focus has been on neurological disease, brain health and psychological functioning (behavior, cognition, and emotion).
The hyperbole aside, there has been considerable progress in the past decade in our understanding of the contribution of specific nutrients and dietary patterns to brain development, physiology, and functioning. This Special Issue of Brain Sciences is devoted to the latest research on the role of nutritional deficiencies and excesses in the genesis of brain dysfunction, and use of diet for the prevention and treatment of brain and mental disorders. Basic laboratory and clinical research studies of the immature, adult, and aged nervous system are all welcome.